Hyaluronic Acid vs. Polyglutamic Acid vs. Glycerin: Which Hydrator Wins?

Published: 4 Dec 2025 • Updated: 4 Dec 2025
A texture comparison of three skincare hydrators: Glycerin (watery), Hyaluronic Acid (viscous), and Polyglutamic Acid (glossy gel).
Can I use Hyaluronic Acid and Polyglutamic Acid together?
Yes! In fact, they are a power couple. Apply your Hyaluronic Acid first (on damp skin) to hydrate deep down, and apply Polyglutamic Acid second to seal the surface. This creates a "double-lock" effect.
Is Glycerin better than Hyaluronic Acid for acne?
Glycerin is generally considered safer for fungal acne (malassezia) triggers, whereas some Hyaluronic Acid serums contain oils or esters that can trigger breakouts. However, pure HA is also acne-safe.
Why does my serum feel sticky?
Stickiness is usually caused by high molecular weight Hyaluronic Acid sitting on the surface of the skin without absorbing. Polyglutamic Acid tends to dry down to a smoother, silkier finish, which is why makeup wearers often prefer it.

If you spend enough time on skincare subreddits, you will notice a shift. The ingredient that was once the undisputed king of hydration—Hyaluronic Acid (HA)—is facing a backlash.

Users are complaining about stickiness, "pilling" under makeup, or the dreaded drying effect we discussed in our previous guide.

Enter the challengers: Glycerin, the unsexy workhorse, and Polyglutamic Acid (PGA), the trendy upgrader.

Which one actually hydrates best? We analyzed the science and the Reddit consensus to declare a winner.

The Incumbent: Hyaluronic Acid (HA)

The Challenger: Glycerin

The Upgrader: Polyglutamic Acid (PGA)

The Verdict: Do You Need to Choose?

The Reddit consensus is that these ingredients are not enemies; they are teammates.

You don't necessarily need three different bottles. The best serums on the market today often combine at least two of these. For example, The Inkey List has a standalone PGA serum that Redditors love layering over their HA serum to lock it in.

Find Your Perfect Match

If you are sticking with Hyaluronic Acid but want a formula that includes Glycerin for better barrier support, or one that avoids the infamous "stickiness," you need to look at the ingredient lists carefully.

We have done the hard work for you. We analyzed hundreds of discussions to rank the best serums on the market. Check out our Best Hyaluronic Acid Serums Ranked list to find the formulas that verify verified buyers actually repurchase.

Bonus: How to Layer Hydrators for Maximum Moisture

  • Start with Glycerin or Watery HA
  • Apply your thinnest, most watery products first. This is usually a toner containing Glycerin or a low-molecular-weight Hyaluronic Acid.

  • Apply Thicker HA Serums
  • If you use a viscous HA serum (like Hada Labo Premium), apply it next. Press it into the skin.

  • Finish with Polyglutamic Acid
  • Because PGA has large molecules that sit on top of the skin, apply it last (before your moisturizer). This seals in the previous layers.

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Sources

• Author: Thomas Oh
• Editor: Thorough Beauty Editorial Team, last reviewed on 4 Dec 2025
• Reading Time: 3 minutes