Abbvie/Allergan (the companies that make Skin Medica) have an employee program in which employees can get the products for deeply discounted prices. It would surprise me if they would open themselves up to internal liability that way, but I've been surprised before with pharma conduct. The case was settled out of court in 2018. Looking at the literature, the risk appears theoretical, and would be similar to the rest of the companies who use growth factors in their serums (like Merz). They likely do not have enough long term follow up data to conclude one way or another, as cancer can take many years to develop.

I asked my derm that question about a different product with human growth factors, as I have a history of skin cancer. She said there's no evidence that it's dangerous and she uses them in her own routine.

Remember you will only find it worth it if you have skin issues that GF [growth factor] will address. If you're young, have no set fine lines or have healthy skin with minimal damage/scarring you probably won't see any difference at all and it won't be worth it. Those are the types of people who I see post reviews and claim that it did nothing at all.

My husband and I both use the TNS serum. He jumped on the bandwagon after seeing my results. In fact, just today we were looking at photos and he remarked that my 3 chicken pock scars from my face are gone. GONE GONE. I have had those scars since I was 6 and I'm now 48. I believe TNS and Tretinoin have taken decades off my face and I now have zero texture.

I am glad it helped you. My experience was opposite. I used the whole bottle of TNS advanced + serum and didn't see any results or any improvements. None. Very disappointing considering it's crazy price tag. I am 41.

Yes and no. I like the stuff, and it does work. I keep thinking it doesn't, then go back to it and look better. BUT, after using TNS advanced for over a year, now maybe closer to 2, I think other GF serums work better for me for wrinkles and deep lines. I like TNS a lot for overall face looking firm and something hard to be specific about but looking better and younger. But it was night and day on deep lines with neocutis for me being WAY better. So now I use TNS in AM to get good tightening plus other at PM.

I love this! I use this everyday and have been for the past year. My only complaint is the dual pump. I'm awaiting a replacement because 1 side of the pump wasn't pumping

Absolutely do not buy from Dermstore. They advertise the new bottle and sell the old bottle and it's defective every time. Even upside down. Even pressing the air out. Even doing all the tricks it DOES NOT work and they refuse to replace it.

I used SkinMedica's live chat option and asked this question. The response was literally this: The TNS Advance + serum is for: Rejuvenate skin, Reduced appearance of fine lines and wrinkles, Enhanced skin texture and tone. And the TNS recovery is: Rejuvenate skin, Reduced appearance of fine lines and wrinkles, Enhanced skin texture and tone. I was like, umm, so they do the same exact thing? And then she just referred me to the medical info team. So I thought I would come here for help.... Anyone know what the difference might be between these two products?

[guidance provided in the follow on comments...]

I used it for about two years before finally switching back to the classic TNS, and I don't miss it. TNS Advanced+ Serum contains a lower concentration of TNS, AND it doesn't include Vitamin C, green tea, CoQ10, arbutin, or ergothioneine like TNS Essential Serum did. Yes, it begins to work faster and it doesn't have that distinctive scent, but absolutely none of my autistic-special-interest-level skincare research has found any signs that TNS Advanced+ Serum provides better results than classic.

Yes - BUT unless you have procedures regularly you're just as well off with the TNS recovery complex which is $65 dollars cheaper. Another trick with all the Skinmedica products is using half a pump - it's really all you need and it will last you a much longer time. I'm on my third eye cream, but everything else has lasted months using a half a pump 2x a day. Also, do not buy this from Amazon or Sam's Club - if it doesn't cost around $200 it's not real.